Clinical Studies

The clinical studies included in this section attest to both the safety and effectiveness of Silybin Phytosome, the active ingredient in Maximum Milk Thistle™ and UltraThistle®.

The reason these studies were originally conducted was to have Silybin Phytosome introduced as a pharmaceutical drug in Europe. Unlike here in the U.S., European doctors take botanical medicine very seriously. Physicians prescribe herbal preparations on a regular basis for specific conditions and diseases.

  • (Ref20C15) Effect of Silybin Phytosome on chronic active hepatitis:

    Study shows significant reduction in elevated liver enzymes (and therefore hepatocellular necrosis) in just one week of treatment with Silybin Phytosome.

  • (Ref21C13) Therapeutic effect of Silybin Phytosome in chronic liver disease:

    A small study of eight human subjects with chronic active hepatitis. This study shows significant benefits of Silybin Phytosome after just two months treatment.

  • (Ref8P22) Direct comparison of Silybin Phytosome to standardized milk thistle extract:

    Study shows nearly 10x the bioavailability of Silybin Phytosome over the world’s best selling standardized extract.

  • (Ref18C14) Useful dosages of Silybin Phytosome:

    Shows definite advantages of Silybin Phytosome at dosages ranging from 160mg to 360mg (measured as silybin). Dose/effect relationship is also demonstrated with the highest dosage tested getting the most dramatic results.

  • (c10) Considerably greater bioavailability of silybin as a component of Silybin Phytosome:

    Laboratory study shows that binding silybin with phosphatidylcholine on a molecular level dramatically improves its bioavailablity on a cellular level.

  • (c3medline) Increased oral bioavailability of Silybin Phytosome in humans:

    Human study compares Silybin Phytosome and the worlds best selling standardized milk thistle extract and shows how much better the results are with Silybin Phytosome.

  • (Ref9C8) Effect of Silybin Phytosome on cirrhotic patients:

    Study shows that Silybin Phytosome does not significantly differ in its safe and beneficial activity in patients with cirrhosis vs. healthy control subjects.

  • (Ref12P19) Liver damage control properties of Silybin Phytosome:

    Silybin Phytosome shows significant protective activity against liver damage. This study tested Silybin Phytosome protection against a variety of toxins.

  • (Ref13P6) Free radical scavenging properties of Silybin Phytosome:

    Study shows the capability of Silybin Phytosome to scavenge free radicals and inhibit lipid peroxidation. It also demonstrates significantly higher blood plasma levels of silybin when administered as a component of Silybin Phytosome rather than in its unbound form.

  • (Ref14P13) Effect of silimarin on lipid peroxidation:

    Study shows milk thistle extract (silymarin) to be a helpful antioxidant and silybin to be the most valuable constituent of silymarin.

  • (Ref15P16) Silybin Phytosome counteracts hepatotoxic effects:

    Study shows Silybin Phytosome protects liver cells against free-radical mediated toxic liver injury.

  • (Ref16P23) Antioxidant activity of Silybin Phytosome against alcohol:

    Study shows how Silybin Phytosome is dramatically more effective than pure silybin alone. Concludes Silybin Phytosome may be useful in counteracting damage caused by alcohol intake.

  • (Ref19C6) Tolerablility and effectiveness of Silybin Phytosome:

    Study shows high dose tolerability of Silybin Phytosome as well as its increased effectiveness over conventional standardized milk thistle extract.

  • (c6medline) Liver protection potential of Silybin Phytosome:

    Study shows the antioxidant and free radical scavenging effect of Silybin Phytosome.

  • (Ref7P12) Comparative bioavailability of Silybin Phytosome vs. silybin:

    Study shows exactly how much better silybin is absorbed when combined on a molecular level with phosphatidylcholine (a patented process resulting in Silybin Phytosome).

  • (Ref11P1) Liver protective activity:

    Shows Silybin Phytosome is more effective than its constituents, silybin and phosphatidylcholine, alone. The effectiveness of Silybin Phytosome is considerably greater than the sum of its parts.

  • Silymarin treatment of viral hepatitis: a systematic review

    Shows silymarin compounds likely decrease serum transaminases in patients with chronic viral hepatitis, but do not appear to affect viral load or liver histology.

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