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Liver Fibrosis

What Causes Liver Fibrosis?

Fibrosis occurs when excessive scar tissue builds up faster than it can be broken down and removed from the liver. Chronic infection with hepatitis C or hepatitis B virus (HCV or HBV), heavy alcohol consumption, toxins, trauma or other factors can all lead to liver fibrosis. Only in rare instances is liver fibrosis the primary problem; more often, it is secondary to some other liver disease such as cirrhosis.

Normally, the body’s response to injury is the formation of scar tissue. In the case of fibrosis, the healing process goes haywire. When hepatocytes (functional liver cells) are injured due to a virus, alcohol, toxins, trauma or other factors, the immune system goes to work to repair the damage. During the fibrosis process, the injured hepatocytes cause substances to be released into the liver causing the buildup of the scar tissue.

HCVadvocate.org “Disease Progression: What is Fibrosis? http://www.hcvadvocate.org/hepatitis/factsheets_pdf/Fibrosis.pdf Retrieved March 28, 2011

HIVandHepatitis.com “Non-Invasive Ways to Assess Liver Disease: Studies Test Alternatives to Liver Biopsy”http://www.hivandhepatitis.com/hep_c/news/2008/020508_b.html/ Retrieved March 28, 2011

Home Health Guide “Liver Fibrosis” http://medicallywiseinfo.com/2010/757/liver-fibrosis.html/ Retrieved March 28, 2011

Mayo Clinic “Mayo Clinic Innovation Aids in Diagnosing Hepatic Fibrosis” http://www.mayoclinic.org/news2009-sct/5160.html/ Retrieved March 28, 2011

National Digestive Diseases Information Clearinghouse NDDIC “Chronic Hepatitis C: Current Disease Management – Liver Biopsy” http://digestive.niddk.nih.gov/ddiseases/pubs/chronichepc/ Retrieved March 28, 2011

PubMed.gov “Liver Fibrosis” http://www.ncbi.nlm.nih.gov/pubmed/15690074/ Retrieved March 28, 2011

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