Clinical Study - Ref7P12
European Journal of Drug Metabolism and PharmacoKinetics, 1992, Vol. 17, No. 1, pp.39-44
Silybin Phytosome versus Silybin
Comparative bioavailability of IbD 1016 (Silybin Phytosome), a new flavanolignan complex, in rats
P. Morazzoni1, M.J. Magistretti1, C. GIACHETTI2 and G. ZANOLO2
1 Inverni della Beffa Rasearch and Development Laboratories, Milan, Italy
2 "Antoine Marxer" Institute for Biomedical Research, Ivrea, Italy
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The results of this study indicate a superior bioavailabilty of silybin administered orally as IbD 1016 (Silybin Phytosome). This was due mainly to an impressive increase in gastrointestinal absorbtion.
It also clearly confirmed that pure silybin has a very low bioavailability; indeed, administered by oral route it does not result in detectable plasma levels of either unmodified or total silybin.