Acute Liver Failure

Who is at Risk for Developing Acute Liver Failure?

Acute liver failure often affects young persons and carries a high morbidity and mortality. Risk factors for developing ALF are as follows:

  • People that take an extremely large dose of acetaminophen at one time or a smaller dose over a period of a few days.
  • Failure to follow dosage instructions for prescription medications and over-the-counter pain relievers and herbal medicines.
  • Failure to follow manufacturer’s instructions when using aerosol sprays, pesticides, cleaning fluids and other toxic chemicals. (Always wear protective clothing such as gloves, a mask, protective eyewear and a hat.)
  • Failure to get vaccinated for Hepatitis A and B.
  • Use of illicit drugs, engaging in unprotected sex, obtaining a tattoo or body piercing in an unsanitary environment or with unsanitary equipment
  • Failure to exercise caution when handling needles or cleaning up bodily fluids or blood.
  • Failure to inform one’s doctor of all prescription drugs, herbal remedies and over-the-counter medications that one is taking to prevent dangerous interactions.
  • Consumption of excessive amounts of alcohol.
  • Obesity – (While obesity is not known to cause ALF, studies show that obese and severely obese patients had significantly poorer outcomes when they developed acute liver failure.)

Mayo Clinic “Acute Liver Failure” http://www.mayoclinic.com/health/liver-failure/DS00961. Retrieved May 20, 2011

Medscape “Diagnosis and Management of Acute Liver Failure” http://www.medscape.com/viewarticle/720697_3. Retrieved May 20, 2011

Palmer, M.D., Melissa. Dr. Melissa Palmer’s Guide to Hepatitis & Liver Disease. New York: Avery Trade, 2004.

U.S. National Library of Medicine NIH National Institutes of Health “Acute liver failure caused by 'fat burners' and dietary supplements: a case report and literature review” http://www.ncbi.nlm.nih.gov/pubmed/21499580. Retrieved May 20, 2011

U.S. National Library of Medicine NIH National Institutes of Health “Influence of high body mass index on outcome in acute liver failure” http://www.ncbi.nlm.nih.gov/pubmed/16996806. Retrieved May 20, 2011

Worman, MD Howard J. The Liver Disorders and Hepatitis Sourcebook. McGraw-Hill, 2006

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