Ref15P16
Biochemical Pharmacology, Vol. 43, No. 10, pp
2111-2115, (1992)
Lipid
Peroxidation and Irreversible Damage in the Rat Hepatocyte
Model
Protection
by The silybin-phosopholipid Complex IdB 1016
Rita
Carini, Adriana Comoglio, Emanuele Albano and Giuseppe Poli*
Department
of Experimental Medicine and Oncology, University of Turin,
CNR Centre of Immunogenetics and Experimental Oncology, Corso
Raffaello 30, Torino, Italy
See
National Library of Medicine Citation
Abstract-IdB
1016 (Silybin Phytosome) is a new silybin-phospholipid complex
which is more bioavailable than the flavonoid silybin itself
and displays free radical scavenging and antioxidant properties
in liver microsomes. IdB 1016 (Silybin Phytosome) at the concentration
which completely prevented MDA formation also protected isolated
hepatocytes against toxicity. Similar protection was also
obtained in hepatocytes prepared in vivo with IdB 1016 (Silybin Phytosome)
while rat supplementation with pure silybin was totally inefficient.
These results indicate IdB 1016 (Silybin Phytosome) as being a
potentially useful protective agent against free radical-mediated
toxic liver injury.
Moreover,
it was demonstrated here for the first time that IdB 1016
(Silybin Phytosome) can counteract the hepatotoxic effect of several
different compounds acting through oxidative mechanisms, indicating
the potential usefulness of the compound as a hepatoprotective
agent.
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