Ref13P6
Free
Rad. Res. Comms., Vol. 11, Nos. 1-3, pp.109-115
Studies
on the Antioxidant and Free Radical Scavenging Properties
of IdB 1016 (Silybin Phytosome) A New Flavanolignan Complex
A.
Comoglio, G. Leonarduzzi, R. Carini, D. Busolin, H. Basaga*,
E. Albano, A. Tomasi**, G. Poli, P. Morazzoni***, and M.J.
Magistretti
*Department
of Experimental Medicine and Oncology, University of Turin,
**Institute of General Pathology, University of Modena and
***Inverni della Beffa Research and Development Laboratories,
Milan, Italy
See
National Library of Medicine Citation
Flavonoids
are a wide group of plant-derived compounds which have been
demonstrated to have antihepatotoxic effects. Among the flavonoids
the purified extract of Silybum marianum (silymarin) and its
main active constituent silybin have received substantial
attention because of their antioxidant properties.
Nonetheless,
the possible application of these flavonoids in therapy is
hampered by their low solubility in water and by the poor
enteral absorption. In order to increase absorption silybin
has been complexed on a molecular level with phosphatidylcholine
to create IdB 1016 (Silybin Phytosome). After oral administration
of IdB 1016 (Silybin Phytosome) to rats the plasma levels of silybin
were found to be significantly higher than those present after
the administration of either uncomplexed silybin or silymarin
to humans (1).
In
conclusion of this study it was found that IdB 1016 (Silybin Phytosome)
is able to reach intracellular sites at concentrations which
make it effective as an antioxidant. It was also proven to
target the liver preferentially. Also, the fact that it is
capable of scavenging free radicals and inhibit lipid peroxidation
suggests that this compound may be potentially useful to protect
against free radical-mediated toxic damage.
1.
N. Barzaghi, G. Perucca, G. Pifferi and A. Crema, (1989) Single-dose
pharmacokinetic study of IdB 1016 (Silybin Phytosome), a new flavanolignan
complex in man. European Journal of Clinical Pharmacology,
36 (suppl.), A110
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